The diverse ways to determine experimental dose in animals
نویسندگان
چکیده
Acute toxicity is manifested in terms of effects which occur after a single administration or relatively brief exposure to substance mixture. The evidence for acute usually obtained from animal testing so characterised lethality and times used experimental protocols. Mainly two hazardous classes are reported that known as “Acute toxicity” “STOT-SE (Specific Target Organ Toxicity-Single Exposure)”. This classification based upon the evident commonly LD50/LC50 value. STOT-SE should be considered where there clear specific organ, especially when it observed absence lethality. Once value determined, then estimate (ATE) could decided therefore accurate measurement LD50 cardinal understand dose responses experimentations. Current review entails diverse method determination along with their merits demerits. Also, unfolds why three alternative methods i.e., fixed procedure (FDP), class (ATC) up down revealed wide acceptance scientific community even though classical were present.
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ژورنال
عنوان ژورنال: Hospice & palliative medicine international journal
سال: 2022
ISSN: ['2576-4497']
DOI: https://doi.org/10.15406/hpmij.2022.05.00202